deleting local user profile on RDS without reboot

I need to delete the local profile for a user on our RDS server, because of a problem with this user.

Since the user was using RDS a few days ago, and RDS wasn’t rebooted since, I can’t delete the local profile. When I go to advanced system settings—user profiles. The ‘delete’ option is greyed out.

I know that I can reboot the server then will be able to delete it, but since this server is serving many users, it means they all have to stop using it.

Is there a way to delete this user’s profile without rebooting the server?

I use sever 2008 R2.